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Identifying and targeting PSMA

Learn about what PSMA is, and how it can be used as both a diagnostic and therapeutic target for metastatic castration-resistant prostate cancer (mCRPC).

Understanding PSMA as a diagnostic and therapeutic  target for mCRPC

What is PSMA?1

Prostate-specific membrane antigen, or PSMA, is a biomarker used for the diagnosis of prostate cancer.

PSMA is naturally found in the prostate gland and other healthy tissues, however its expression is increased in prostate cancer lesions making it a valuable imaging marker and therapy target for the disease.

High levels of PSMA have been directly linked with more aggressive prostate cancer:

5-year recurrence-free survival rates based on PSMA levels

88.2%

in patients exhibiting no PSMA presence

74.2%

in patients exhibiting low PSMA presence

67.7%

in patients exhibiting medium PSMA presence

26.8%

in patients exhibiting high PSMA presence